First things first: Caffeinated Content for WordPress has been updated to version 2.8.0 with a quick fix to a problem with longtail keywords. Download in the members area!
Regarding WordPress 2.5. Looks like a pretty nifty little update they’ve got along with some handy features including some plugin jazz. Now, Caffeinated Content for WordPress *SHOULD* work out of the box. I can’t and won’t make any guarantees, however, until they reach a stable release. Too many things can change between now and then. 